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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2006-4-4
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pubmed:abstractText |
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0920-9964
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pubmed:author |
pubmed-author:AoyamaNagisaN,
pubmed-author:IkedaMasashiM,
pubmed-author:InadaToshiyaT,
pubmed-author:IshiharaRyokoR,
pubmed-author:IwataNakaoN,
pubmed-author:JiXiofeiX,
pubmed-author:KinoshitaYokoY,
pubmed-author:KitajimaTsuyoshiT,
pubmed-author:MaemoNobuhisaN,
pubmed-author:MiuraHidekiH,
pubmed-author:OzakiNorioN,
pubmed-author:SaitoShinichiS,
pubmed-author:SuzukiTatsuyoT,
pubmed-author:TakahashiNagahideN,
pubmed-author:YamanouchiYoshioY
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pubmed:issnType |
Print
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|
pubmed:volume |
83
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
179-83
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:16504480-Adult,
pubmed-meshheading:16504480-Case-Control Studies,
pubmed-meshheading:16504480-Chromogranin A,
pubmed-meshheading:16504480-Chromogranins,
pubmed-meshheading:16504480-Female,
pubmed-meshheading:16504480-Gene Frequency,
pubmed-meshheading:16504480-Genetic Predisposition to Disease,
pubmed-meshheading:16504480-Genotype,
pubmed-meshheading:16504480-Humans,
pubmed-meshheading:16504480-Japan,
pubmed-meshheading:16504480-Male,
pubmed-meshheading:16504480-Middle Aged,
pubmed-meshheading:16504480-Polymorphism, Genetic,
pubmed-meshheading:16504480-Schizophrenia,
pubmed-meshheading:16504480-Sequence Analysis
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pubmed:year |
2006
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pubmed:articleTitle |
Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population.
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pubmed:affiliation |
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
