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rdf:type |
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lifeskim:mentions |
umls-concept:C0005684,
umls-concept:C0007328,
umls-concept:C0028798,
umls-concept:C0032529,
umls-concept:C0035647,
umls-concept:C0037369,
umls-concept:C0311400,
umls-concept:C0332157,
umls-concept:C0442805,
umls-concept:C0596244,
umls-concept:C0682958,
umls-concept:C1418251
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-12-25
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pubmed:abstractText |
To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Air Pollutants, Occupational,
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Arylamine N-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Arylsulfotransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/NAT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Hydrocarbons, Aromatic,
http://linkedlifedata.com/resource/pubmed/chemical/SULT1A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vehicle Emissions,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase M1,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase T1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
245
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-60
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:16504378-Aged,
pubmed-meshheading:16504378-Aged, 80 and over,
pubmed-meshheading:16504378-Air Pollutants, Occupational,
pubmed-meshheading:16504378-Amines,
pubmed-meshheading:16504378-Arylamine N-Acetyltransferase,
pubmed-meshheading:16504378-Arylsulfotransferase,
pubmed-meshheading:16504378-Female,
pubmed-meshheading:16504378-Genotype,
pubmed-meshheading:16504378-Glutathione Transferase,
pubmed-meshheading:16504378-Humans,
pubmed-meshheading:16504378-Male,
pubmed-meshheading:16504378-Middle Aged,
pubmed-meshheading:16504378-Occupational Exposure,
pubmed-meshheading:16504378-Odds Ratio,
pubmed-meshheading:16504378-Polycyclic Hydrocarbons, Aromatic,
pubmed-meshheading:16504378-Polymorphism, Genetic,
pubmed-meshheading:16504378-Risk Assessment,
pubmed-meshheading:16504378-Risk Factors,
pubmed-meshheading:16504378-Smoking,
pubmed-meshheading:16504378-Urinary Bladder Neoplasms,
pubmed-meshheading:16504378-Vehicle Emissions
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pubmed:year |
2007
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pubmed:articleTitle |
Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk.
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pubmed:affiliation |
Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Belgium. eliane.kellen@med.kuleuven.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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