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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2006-3-27
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pubmed:abstractText |
In vitro immunization with HCV lipopeptide aa 20-44 results in antigen-specific T cells. Here, we studied whether presentation of the lipopeptide by dendritic cells (DC) results in enhanced T cell functions. DC-immunized T cells showed significantly augmented proliferation and IFN-gamma secretion upon HCV-specific re-stimulation. This effect was related to significantly increased expression of TLR2 on DC-immunized CD4+ T cells and required TLR2 triggering during re-stimulation. In contrast, numbers of HLA-A2-pentamer-positive CD8+ T cells and granzyme B-secreting T cells remained unchanged. Thus, up-regulation of TLR2 during immunization with DC enhances functions of CD4+ T cells but not CD8+ T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/GZMB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/TLR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tripalmitoyl cysteine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3066-75
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16504351-Adjuvants, Immunologic,
pubmed-meshheading:16504351-Adult,
pubmed-meshheading:16504351-Antigen Presentation,
pubmed-meshheading:16504351-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16504351-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16504351-Cell Proliferation,
pubmed-meshheading:16504351-Cysteine,
pubmed-meshheading:16504351-Dendritic Cells,
pubmed-meshheading:16504351-Female,
pubmed-meshheading:16504351-Granzymes,
pubmed-meshheading:16504351-Hepacivirus,
pubmed-meshheading:16504351-Humans,
pubmed-meshheading:16504351-Immunization,
pubmed-meshheading:16504351-Interferon-gamma,
pubmed-meshheading:16504351-Lipoproteins,
pubmed-meshheading:16504351-Lymphocyte Subsets,
pubmed-meshheading:16504351-Male,
pubmed-meshheading:16504351-Middle Aged,
pubmed-meshheading:16504351-Serine Endopeptidases,
pubmed-meshheading:16504351-Toll-Like Receptor 2,
pubmed-meshheading:16504351-Up-Regulation,
pubmed-meshheading:16504351-Viral Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2.
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pubmed:affiliation |
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. bettina.langhans@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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