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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-3-13
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pubmed:abstractText |
Several studies have compared various features of heritable disease genes with other so called non-disease genes, but they have yielded some conflicting results. A potential problem in those studies is that the non-disease genes contained a large number of essential genes--genes which are indispensable for humans to survive and reproduce. Since a functional disruption of an essential gene has fatal consequences, it's more reasonable to regard essential genes as extremely severe "disease" genes. Here we perform a comparative study on the features of human essential, disease, and other genes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-10545467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-10935514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11015593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11237009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11333967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11429604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11689479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11773595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-11875032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12045149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12140549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12196633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12519980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12716985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12850439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-12966136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-14525934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-14585509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-14595094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-14681465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15075390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15181176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15239832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15608221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15608251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15766383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15791247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-15840711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-16024819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-8308912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-8587116,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-9689093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16504025-9851918
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16504025-Adolescent,
pubmed-meshheading:16504025-Adult,
pubmed-meshheading:16504025-Age of Onset,
pubmed-meshheading:16504025-Animals,
pubmed-meshheading:16504025-Caenorhabditis elegans,
pubmed-meshheading:16504025-Child,
pubmed-meshheading:16504025-Child, Preschool,
pubmed-meshheading:16504025-Classification,
pubmed-meshheading:16504025-Codon,
pubmed-meshheading:16504025-Evolution, Molecular,
pubmed-meshheading:16504025-Gene Deletion,
pubmed-meshheading:16504025-Genes,
pubmed-meshheading:16504025-Genes, Essential,
pubmed-meshheading:16504025-Genetic Diseases, Inborn,
pubmed-meshheading:16504025-Genome, Human,
pubmed-meshheading:16504025-Humans,
pubmed-meshheading:16504025-Infant,
pubmed-meshheading:16504025-Infant, Newborn,
pubmed-meshheading:16504025-Phenotype,
pubmed-meshheading:16504025-Protein Interaction Mapping,
pubmed-meshheading:16504025-Saccharomyces cerevisiae
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pubmed:year |
2006
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pubmed:articleTitle |
Further understanding human disease genes by comparing with housekeeping genes and other genes.
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pubmed:affiliation |
Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA. ztu@usc.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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