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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1975-7-23
|
| pubmed:abstractText |
1. The metabolism of an intravenous pulse dose of double-isotope-labelled cholecalciferol has been studied in control subjects with widely differing states of vitamin D nutrition and in patients with primary disorders of parathyroid function. 2. The formation of labelled 1,25-dihydroxy-cholecalciferol [1,25-(OH)2D3] and labelled 24,25-dihydroxycholecalciferol [24,25-(OH)2D3] has been related to the prevailing concentrations in serum of 25-hydroxycholecalciferol [25-(OH)D3], immunoreactive parathyroid hormonel, calcium and orthophosphate (Pi). 3. In control subjects with relative vitamin D deficiency [serum 25-(OH)2D3 was related inversely to the serum 25-(OH)D3 and serum calcium, and directly to serum immunoreactive parathyroid hormone. No formation of 1,25-(OH)2D3 was detectable to form labelled 24,25(OH)2D3 preferentially. 4. No control subject produced significant amounts of both labelled 1,25-(OH)2D3 and labelled 24,25-(OH)2D3 simultaneously. 5. All subjects with primary hyperparathyroidism produced significant amounts of labelled 1,25-(OH)2D3 and labelled 24,25-(OH)2D3 simultaneously; the renal turnover of 25-(OH)D3 was apparently greater than in nutritionally matched controls. Serum labelled 1,25-(OH)2D3 in this disease was not correlated with serum 25-(OH)D3, immunoreactive parathyroid hormone, calcium or Pi. Production of labelled 24,25-(OH)2D3 was inappropriately high for the prevailing nutritional state. 6. The indirectly estimated their concentration of 1,25-(OH)2D3 showed only a fourfold variation in control subjects (45-180 pmol/l), compatible with its having a regulated hormonal function. 7. The data suggest that the production of 1,25-(OH)2D3 from a pulse dose of cholecalciferol is normally regulated, directly or indirectly, by the parathyroid hormone.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cholecalciferol,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroxycholecalciferols,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0301-0538
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
349-65
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:165031-Adult,
pubmed-meshheading:165031-Aged,
pubmed-meshheading:165031-Alkaline Phosphatase,
pubmed-meshheading:165031-Biopsy,
pubmed-meshheading:165031-Bone and Bones,
pubmed-meshheading:165031-Calcium,
pubmed-meshheading:165031-Cholecalciferol,
pubmed-meshheading:165031-Creatinine,
pubmed-meshheading:165031-Dihydroxycholecalciferols,
pubmed-meshheading:165031-Female,
pubmed-meshheading:165031-Humans,
pubmed-meshheading:165031-Male,
pubmed-meshheading:165031-Middle Aged,
pubmed-meshheading:165031-Osteitis Fibrosa Cystica,
pubmed-meshheading:165031-Parathyroid Glands,
pubmed-meshheading:165031-Parathyroid Hormone,
pubmed-meshheading:165031-Radioimmunoassay,
pubmed-meshheading:165031-Radioligand Assay
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Vitamin D metabolism and parathyroid function in man.
|
| pubmed:publicationType |
Journal Article
|