| pubmed-article:16501569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16501569 | lifeskim:mentions | umls-concept:C1333282 | lld:lifeskim |
| pubmed-article:16501569 | lifeskim:mentions | umls-concept:C1413850 | lld:lifeskim |
| pubmed-article:16501569 | lifeskim:mentions | umls-concept:C1155013 | lld:lifeskim |
| pubmed-article:16501569 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16501569 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16501569 | pubmed:dateCreated | 2006-3-21 | lld:pubmed |
| pubmed-article:16501569 | pubmed:abstractText | T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically interacted with active Lck and promoted recruitment of active Lck to its substrate, Zap70. CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck. Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells. | lld:pubmed |
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| pubmed-article:16501569 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16501569 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16501569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16501569 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16501569 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:RoeP LPL | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:NorburyChrist... | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:SunShao-CongS... | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:ZhangMinyingM | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:DonohueKeri... | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:ReileyWilliam... | lld:pubmed |
| pubmed-article:16501569 | pubmed:author | pubmed-author:LosiewiczMand... | lld:pubmed |
| pubmed-article:16501569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16501569 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16501569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16501569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16501569 | pubmed:pagination | 411-7 | lld:pubmed |
| pubmed-article:16501569 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16501569 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16501569 | pubmed:articleTitle | Regulation of T cell development by the deubiquitinating enzyme CYLD. | lld:pubmed |
| pubmed-article:16501569 | pubmed:affiliation | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. | lld:pubmed |
| pubmed-article:16501569 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16501569 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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