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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0079337,
umls-concept:C1420812,
umls-concept:C1446680,
umls-concept:C1515877,
umls-concept:C1550548,
umls-concept:C1555714,
umls-concept:C1704675,
umls-concept:C1705294,
umls-concept:C1705654,
umls-concept:C1749467,
umls-concept:C1879547
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pubmed:issue |
6
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pubmed:dateCreated |
2006-2-27
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pubmed:abstractText |
Recombinant soluble CD134 (sCD134) facilitated feline immunodeficiency virus (FIV) entry into CXCR4-positive, cell surface CD134-negative target cells. sCD134-activated entry was dose dependent and CXCR4 dependent. We used the sCD134 activation system to explore the neutralization by four anti-V3 monoclonal antibodies (MAbs). V3 MAbs weakly neutralized FIV infection using target cells expressing both CD134 and CXCR4 but potently inhibited sCD134-activated entry into target cells expressing CXCR4 alone. These findings provide direct evidence for a sequential interaction of FIV Env with CD134 and CXCR4 and reveal the presence of a cryptic epitope in V3 that is masked in the mature envelope oligomers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-10332739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-10358771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-10400783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-11312323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-11403007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-12584309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-1374840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-14976315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-15308694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-15308709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-15326292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-15592478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-1697907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7510240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7512121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7543872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7636470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7678301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7686186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-7966629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-8259661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-8392611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-8547142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-8627265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-8911003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16501119-9282817
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV envelope protein gp120 (305-321),
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3088-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16501119-Amino Acid Sequence,
pubmed-meshheading:16501119-Animals,
pubmed-meshheading:16501119-Cats,
pubmed-meshheading:16501119-Epitopes,
pubmed-meshheading:16501119-Gene Expression Regulation, Viral,
pubmed-meshheading:16501119-Gene Products, env,
pubmed-meshheading:16501119-Genes, env,
pubmed-meshheading:16501119-HIV Envelope Protein gp120,
pubmed-meshheading:16501119-Immunodeficiency Virus, Feline,
pubmed-meshheading:16501119-Molecular Sequence Data,
pubmed-meshheading:16501119-Neutralization Tests,
pubmed-meshheading:16501119-Peptide Fragments,
pubmed-meshheading:16501119-Receptors, CXCR4,
pubmed-meshheading:16501119-Receptors, OX40,
pubmed-meshheading:16501119-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16501119-Solubility
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pubmed:year |
2006
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pubmed:articleTitle |
Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.
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pubmed:affiliation |
The Scripps Research Institute, Department of Molecular Biology, MB-14, 10550 N. Torrey Pines Rd., La Jolla, California 92037, USA. parseval@scripps.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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