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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
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pubmed:dateCreated |
2006-4-3
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pubmed:abstractText |
A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2719-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16500101-Animals,
pubmed-meshheading:16500101-Blood Glucose,
pubmed-meshheading:16500101-Diabetes Mellitus, Experimental,
pubmed-meshheading:16500101-Hypoglycemic Agents,
pubmed-meshheading:16500101-Male,
pubmed-meshheading:16500101-Naphthalenes,
pubmed-meshheading:16500101-Rats,
pubmed-meshheading:16500101-Rats, Sprague-Dawley,
pubmed-meshheading:16500101-Streptozocin
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pubmed:year |
2006
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|
pubmed:articleTitle |
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
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|
pubmed:affiliation |
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. dratulsax@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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