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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-27
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pubmed:abstractText |
Growth/differentiation factor-5 (GDF-5), a member of the transforming growth factor-beta superfamily, shows a close structural relationship to bone morphogenetic proteins and plays crucial roles in skeletal morphogenesis. Recombinant human (rh) GDF-5 was reported as a suitable factor for enhancing healing in bone defect and inducing ectopic bone formation. The purpose of the present study was to investigate the mechanism of bone formation induced by rhGDF-5 in murine calvariae by radiological, histological and immunohistochemical methods. Cell proliferation was also examined in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3484
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16499717-Analysis of Variance,
pubmed-meshheading:16499717-Animals,
pubmed-meshheading:16499717-Bone Morphogenetic Proteins,
pubmed-meshheading:16499717-Cell Movement,
pubmed-meshheading:16499717-Cell Proliferation,
pubmed-meshheading:16499717-Cells, Cultured,
pubmed-meshheading:16499717-Chondrogenesis,
pubmed-meshheading:16499717-Fibroblasts,
pubmed-meshheading:16499717-Growth Differentiation Factor 5,
pubmed-meshheading:16499717-Humans,
pubmed-meshheading:16499717-Immunohistochemistry,
pubmed-meshheading:16499717-Mice,
pubmed-meshheading:16499717-Osteoblasts,
pubmed-meshheading:16499717-Osteogenesis,
pubmed-meshheading:16499717-Periosteum,
pubmed-meshheading:16499717-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:16499717-Recombinant Proteins,
pubmed-meshheading:16499717-Scalp,
pubmed-meshheading:16499717-Skull,
pubmed-meshheading:16499717-Tomography, X-Ray Computed
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pubmed:year |
2006
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pubmed:articleTitle |
Recombinant human growth/differentiation factor-5 (rhGDF-5) induced bone formation in murine calvariae.
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pubmed:affiliation |
Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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