Source:http://linkedlifedata.com/resource/pubmed/id/16499337
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-2-27
|
| pubmed:abstractText |
Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC(50) values ranging from 4 to 6 microM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
295-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16499337-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:16499337-Asteraceae,
pubmed-meshheading:16499337-Drug Screening Assays, Antitumor,
pubmed-meshheading:16499337-Ethers, Cyclic,
pubmed-meshheading:16499337-HL-60 Cells,
pubmed-meshheading:16499337-Humans,
pubmed-meshheading:16499337-Italy,
pubmed-meshheading:16499337-Plant Leaves,
pubmed-meshheading:16499337-Plants, Medicinal,
pubmed-meshheading:16499337-Spiro Compounds
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus.
|
| pubmed:affiliation |
Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|