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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1991-8-23
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pubmed:abstractText |
To measure protection induced by natural rotavirus infection, 163 infants enrolled in a rotavirus vaccine trial were prospectively followed for 2 years. Serotype 1 rotaviruses were the predominant circulating strains during the study. Over the 2 years of observation, significantly fewer infants infected before enrollment developed a symptomatic reinfection (0 of 21) or any reinfection (4 of 21) compared with previously uninfected infants (P = .0003). Of the 60 infants who developed a primary rotavirus infection in the first year (40 symptomatic, 20 asymptomatic) only 4 were reinfected in the second year compared with 29 of 82 subjects not previously infected (P = .00003). Asymptomatic primary infection appeared to be as protective as symptomatic primary infection. The only symptomatic reinfections occurred in 2 subjects who did not develop rotavirus antibody after the initial detection of rotavirus. An age-related reduction in the ratio of symptomatic to asymptomatic primary rotavirus infection was also detected. In this study, protection against homotypic serotype 1 reinfection appeared to last greater than or equal to 2 years.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Rotavirus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/WC3 rotavirus vaccine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-83
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1649875-Age Factors,
pubmed-meshheading:1649875-Antibodies, Viral,
pubmed-meshheading:1649875-Diarrhea,
pubmed-meshheading:1649875-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1649875-Feces,
pubmed-meshheading:1649875-Humans,
pubmed-meshheading:1649875-Immunity, Active,
pubmed-meshheading:1649875-Infant,
pubmed-meshheading:1649875-Prospective Studies,
pubmed-meshheading:1649875-RNA, Viral,
pubmed-meshheading:1649875-Recurrence,
pubmed-meshheading:1649875-Rotavirus,
pubmed-meshheading:1649875-Rotavirus Infections,
pubmed-meshheading:1649875-Rotavirus Vaccines,
pubmed-meshheading:1649875-Serotyping,
pubmed-meshheading:1649875-Viral Vaccines
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pubmed:year |
1991
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pubmed:articleTitle |
Protection from rotavirus reinfection: 2-year prospective study.
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pubmed:affiliation |
Division of Clinical Virology, James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
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pubmed:publicationType |
Journal Article
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