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pubmed-article:16498264pubmed:abstractTextGATA-3 (GATA binding protein 3) and the proto-oncogene c-maf are Th2-regulating transcription factors that control the expression of interleukin (IL)-4 and IL-5, while T-bet (T-box expressed in T cells) is a Th1-specific transcription factor that controls the expression of interferon (IFN-gamma). Allergen provocation in asthmatics induces a Th2-dominated cytokine profile, but so far it is unknown whether the skewed cytokine expression is reflected by the expression of the respective transcriptional regulators.lld:pubmed
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pubmed-article:16498264pubmed:copyrightInfoCopyright (c) 2006 S. Karger AG, Basel.lld:pubmed
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pubmed-article:16498264pubmed:articleTitleRegulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge.lld:pubmed
pubmed-article:16498264pubmed:affiliationFraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany. erpenbeck@item.fraunhofer.delld:pubmed
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