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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-3
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pubmed:abstractText |
GATA-3 (GATA binding protein 3) and the proto-oncogene c-maf are Th2-regulating transcription factors that control the expression of interleukin (IL)-4 and IL-5, while T-bet (T-box expressed in T cells) is a Th1-specific transcription factor that controls the expression of interferon (IFN-gamma). Allergen provocation in asthmatics induces a Th2-dominated cytokine profile, but so far it is unknown whether the skewed cytokine expression is reflected by the expression of the respective transcriptional regulators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/IL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-maf,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:issn |
1018-2438
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2006 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-16
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16498264-Adolescent,
pubmed-meshheading:16498264-Adult,
pubmed-meshheading:16498264-Allergens,
pubmed-meshheading:16498264-Asthma,
pubmed-meshheading:16498264-Biopsy,
pubmed-meshheading:16498264-Bronchi,
pubmed-meshheading:16498264-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:16498264-Female,
pubmed-meshheading:16498264-GATA3 Transcription Factor,
pubmed-meshheading:16498264-Gene Expression Regulation,
pubmed-meshheading:16498264-Humans,
pubmed-meshheading:16498264-Interferon-gamma,
pubmed-meshheading:16498264-Interleukin-4,
pubmed-meshheading:16498264-Interleukin-5,
pubmed-meshheading:16498264-Lymphocyte Count,
pubmed-meshheading:16498264-Male,
pubmed-meshheading:16498264-Proto-Oncogene Proteins c-maf,
pubmed-meshheading:16498264-RNA, Messenger,
pubmed-meshheading:16498264-T-Box Domain Proteins,
pubmed-meshheading:16498264-T-Lymphocyte Subsets,
pubmed-meshheading:16498264-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge.
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pubmed:affiliation |
Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany. erpenbeck@item.fraunhofer.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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