Linked Life Data

16496748

Source:http://linkedlifedata.com/resource/pubmed/id/16496748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-2-24
pubmed:abstractText
Warfarin is the most commonly used vitamin K antagonist (VKA), based on its demonstrated efficacy in the prevention and treatment of venous and arterial thromboembolism. Optimal management of warfarin therapy is a daily challenge, mainly because of its complex pharmacokinetics and pharmacodynamics. In particular, the induction phase of warfarin treatment is unpredictable, thus placing patients to an increased risk of excessive anticoagulation, which predisposes to bleeding, or to prolonged subtherapeutic anticoagulation, which predisposes to thrombosis and often mandates extended therapy with parenteral anticoagulants. A number of algorithms has been developed to initiate warfarin therapy. Unfortunately, most have failed to gain widespread acceptance. In this review we briefly discuss the results of published clinical trials that assessed different initial approaches to warfarin therapy, their main findings and limitations. In summary, we can conclude that there is sufficient evidence to support the use of different starting doses of warfarin based on both individual and disease-specific factors. In particular, younger outpatients require higher starting doses of warfarin (7.5-10 mg) than older and hospitalized patients (2.5-5 mg), and than patients following cardiopulmonary by-pass surgery. However, further clinical studies are necessary to identify the best strategy to individualize warfarin initiation therapy.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0034-1193
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
612-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
[Current issues in the initial phase of warfarin therapy].
pubmed:publicationType
Editorial, English Abstract, Review