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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-3-8
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pubmed:abstractText |
Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies. Our previous study using proteomic profiling showed that significant upregulation of stathmin occurs in oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine the potential involvement of stathmin in OSCC, we evaluated the state of stathmin protein and mRNA expression in OSCC-derived cell lines and human primary OSCCs. A significant increase in stathmin expression was observed in all OSCC-derived cell lines examined compared to human normal oral keratinocytes. In immunohistochemistry, 65% of the OSCCs were positive for stathmin, and no immunoreaction was observed in corresponding normal tissues. Real-time quantitative reverse transcriptase-polymerase chain reaction data were consistent with the protein expression status. Moreover, stathmin expression status was correlated with the TNM stage grading. Furthermore, we found a statistical correlation between the protein expression status and disease-free survival (P=0.029). These results suggest that expression of stathmin could contribute to cancer progression/prognosis, and that stathmin may have potential as a biomarker and a therapeutic target for OSCC.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495930-10708477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495930-10713262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495930-10786892,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16495930-9743287
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:BukawaHH,
pubmed-author:EndoYY,
pubmed-author:HigoMM,
pubmed-author:KasamatsuAA,
pubmed-author:KoikeHH,
pubmed-author:KouzuYY,
pubmed-author:NakashimaDD,
pubmed-author:SaitoKK,
pubmed-author:ShiibaMM,
pubmed-author:TanzawaHH,
pubmed-author:UzawaKK,
pubmed-author:YokoeHH
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
717-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16495930-Aged,
pubmed-meshheading:16495930-Carcinoma, Squamous Cell,
pubmed-meshheading:16495930-Disease-Free Survival,
pubmed-meshheading:16495930-Female,
pubmed-meshheading:16495930-Gene Expression Profiling,
pubmed-meshheading:16495930-Humans,
pubmed-meshheading:16495930-Immunohistochemistry,
pubmed-meshheading:16495930-Keratinocytes,
pubmed-meshheading:16495930-Male,
pubmed-meshheading:16495930-Middle Aged,
pubmed-meshheading:16495930-Mouth Neoplasms,
pubmed-meshheading:16495930-Neoplasm Staging,
pubmed-meshheading:16495930-Prognosis,
pubmed-meshheading:16495930-RNA, Messenger,
pubmed-meshheading:16495930-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16495930-Stathmin,
pubmed-meshheading:16495930-Tumor Cells, Cultured,
pubmed-meshheading:16495930-Tumor Markers, Biological,
pubmed-meshheading:16495930-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis.
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pubmed:affiliation |
Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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