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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-3-8
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pubmed:abstractText |
Mitochondrial DNA mutations have been reported in several types of tumours, including head and neck squamous cell carcinoma (HNSCC). The noncoding region of the Displacement-Loop (D-Loop) has emerged as a mutational hotspot and we recently found that they were associated with prognosis and response to 5 fluorouracil (5FU) in colon cancers. In order to evaluate the frequence of D-Loop mutations in a large series of HNSCC and establish correlations with clinicopathologic parameters, we sequenced the D-Loop of 109 HNSCC before a treatment by neoadjuvant 5FU-cisplatin-based chemotherapy and surgery. Then, we correlated these mutations with prognosis and response to chemotherapy. A D-Loop mutation was identified in 21% of the tumors, the majority of them were located in a C-tract (D310). The prevalence of D310 mutations increased significantly with the number of cytosines in the matched normal tissue sequence (P=0.02). Hypopharyngeal cancer was significantly more frequent (P=0.03) and tobacco consumption more important (P=0.01) in the group of patients with D-Loop mutation. The presence of D-Loop mutation was not associated with prognosis or with response to neoadjuvant chemotherapy. These results suggest that D-Loop mutations should be considered as a cancer biomarker that may be useful for the early detection of HNSCC in individuals at risk of this cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10200525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10328595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10404095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10486591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10597269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10720328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10803467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-10945635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11187439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11291064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11413468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11477557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11507041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11526508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11559538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11585726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11606403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11745228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11745425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-11839667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-12032845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-12055609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-12114429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-12696067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-13298683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15102660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15163006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15167214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15286356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15515158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-15908662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-2671701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-3664791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-7979175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-8000993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-8118797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-8118798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-8740737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-8971177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-9058704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-9199183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-9806551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16495928-9883902
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
692-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16495928-Carcinoma, Squamous Cell,
pubmed-meshheading:16495928-Cisplatin,
pubmed-meshheading:16495928-DNA, Mitochondrial,
pubmed-meshheading:16495928-DNA Mutational Analysis,
pubmed-meshheading:16495928-Female,
pubmed-meshheading:16495928-Fluorouracil,
pubmed-meshheading:16495928-Head and Neck Neoplasms,
pubmed-meshheading:16495928-Humans,
pubmed-meshheading:16495928-Male,
pubmed-meshheading:16495928-Middle Aged,
pubmed-meshheading:16495928-Neoadjuvant Therapy,
pubmed-meshheading:16495928-Predictive Value of Tests,
pubmed-meshheading:16495928-Prognosis,
pubmed-meshheading:16495928-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma.
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pubmed:affiliation |
INSERM U490, Université René Descartes, 45 rue des Saints-Pères, F-75006 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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