Source:http://linkedlifedata.com/resource/pubmed/id/16495630
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-2-23
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| pubmed:abstractText |
Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified Flavivirus. Its clinical significance in chronic hepatitis B and C remains controversial. Infection with HGV/GBV-C was surveyed in 500 blood donors, 130 patients with chronic hepatitis B and 173 with hepatitis C, with chronic liver disease, cirrhosis, and/or hepatocellular carcinoma (HCC). HGV/GBV-C RNA was detected by reverse transcription-polymerase chain reaction. An antibody to HGV/GBV-C's second envelope protein (anti-E2 Ab) was detected using an enzyme immunoassay. The prevalence of HGV/GBV-C RNA was 3.4% and the exposure rate 10.2% in blood donors. The prevalence of HGV/GBV-C RNA in patients with chronic hepatitis B and hepatitis C was 7.7 and 17.3%, respectively (P = 0.002). The prevalence of the HGV/GBV-C infection in hepatitis B carriers increased with the severity of chronic liver disease and risk of HCC. The age and duration of hepatitis B virus infection were the more important contributing factors. Clinical and virological characteristics were comparable between those with and without coinfection of HGV/GBV-C and hepatitis C. The seroconversion rate was high. Coinfection of HGV/GBV-C with hepatitis B or C does not affect disease severity, but accelerates the progression of chronic liver disease and the development of HCC.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1344-6304
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| pubmed:author |
pubmed-author:ChangWen-YuWY,
pubmed-author:ChenShinn-CherngSC,
pubmed-author:ChuangWan-LongWL,
pubmed-author:DaiChia-YenCY,
pubmed-author:HsiehMing-YuhMY,
pubmed-author:LinWen-YiWY,
pubmed-author:LinZu-YauZY,
pubmed-author:TsaiJung-FaJF,
pubmed-author:WangLiang-YenLY,
pubmed-author:YangJeng-FuJF,
pubmed-author:YuMing-LungML
|
| pubmed:issnType |
Print
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
25-30
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16495630-Adult,
pubmed-meshheading:16495630-Antibodies, Viral,
pubmed-meshheading:16495630-Blood Donors,
pubmed-meshheading:16495630-Female,
pubmed-meshheading:16495630-Flaviviridae Infections,
pubmed-meshheading:16495630-GB virus C,
pubmed-meshheading:16495630-Genotype,
pubmed-meshheading:16495630-Hepatitis, Viral, Human,
pubmed-meshheading:16495630-Hepatitis B, Chronic,
pubmed-meshheading:16495630-Hepatitis C, Chronic,
pubmed-meshheading:16495630-Humans,
pubmed-meshheading:16495630-Male,
pubmed-meshheading:16495630-Middle Aged,
pubmed-meshheading:16495630-RNA, Viral,
pubmed-meshheading:16495630-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16495630-Seroepidemiologic Studies,
pubmed-meshheading:16495630-Severity of Illness Index
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C.
|
| pubmed:affiliation |
Department of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|