|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-2-23
|
|
pubmed:abstractText |
Crohn's disease (CD) and Ulcerative Colitis (UC) are related chronic inflammatory disorders of the intestine (IBD) caused by a combination of genetic and environmental factors. Three polymorphisms within the NOD2/CARD15 gene are highly associated with CD, increasing the risk from 2 up to 44-fold, depending on the presence of one or two risk alleles. Aim of this study was to investigate the presence of two risk alleles on healthy relatives of IBD patients and prospectively follow them for possible development of IBD.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1128-3602
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
33-6
|
|
pubmed:dateRevised |
2009-4-16
|
|
pubmed:meshHeading |
pubmed-meshheading:16494109-Abdomen,
pubmed-meshheading:16494109-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:16494109-Family,
pubmed-meshheading:16494109-Gene Frequency,
pubmed-meshheading:16494109-Genetic Predisposition to Disease,
pubmed-meshheading:16494109-Genotype,
pubmed-meshheading:16494109-Humans,
pubmed-meshheading:16494109-Inflammatory Bowel Diseases,
pubmed-meshheading:16494109-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16494109-Italy,
pubmed-meshheading:16494109-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:16494109-Polymorphism, Single Nucleotide,
pubmed-meshheading:16494109-Saccharomyces cerevisiae,
pubmed-meshheading:16494109-Ultrasonography
|
|
pubmed:articleTitle |
NOD2/CARD15 in healthy relatives of IBD patients.
|
|
pubmed:affiliation |
U.O. Gastroenterologia, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
|
|
pubmed:publicationType |
Journal Article
|
