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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1991-8-16
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pubmed:abstractText |
Increased gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathogenesis of hepatic encephalopathy. The mechanism by which GABA-ergic activity is increased in hepatic failure is unclear, but recent studies in animals with encephalopathy due to fulminant hepatic failure suggest that GABA-ergic neurotransmission may be increased by the presence of elevated concentrations of benzodiazepine agonists such as diazepam and N-desmethyldiazepam.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
325
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-8
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1649403-Adult,
pubmed-meshheading:1649403-Aged,
pubmed-meshheading:1649403-Benzodiazepines,
pubmed-meshheading:1649403-Brain Chemistry,
pubmed-meshheading:1649403-Chromatography,
pubmed-meshheading:1649403-Diazepam,
pubmed-meshheading:1649403-Flumazenil,
pubmed-meshheading:1649403-Frontal Lobe,
pubmed-meshheading:1649403-Hepatic Encephalopathy,
pubmed-meshheading:1649403-Humans,
pubmed-meshheading:1649403-Mass Spectrometry,
pubmed-meshheading:1649403-Middle Aged,
pubmed-meshheading:1649403-Nordazepam,
pubmed-meshheading:1649403-Receptors, GABA-A,
pubmed-meshheading:1649403-Synaptic Transmission,
pubmed-meshheading:1649403-gamma-Aminobutyric Acid
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pubmed:year |
1991
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pubmed:articleTitle |
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
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pubmed:affiliation |
Laboratory of Neuroscience, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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