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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-22
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pubmed:abstractText |
Gastroesophageal reflux disease is a risk factor for the development of Barrett's esophagus and esophageal adenocarcinoma. The effect of antireflux therapy on the incidence of esophageal adenocarcinoma is unknown. Acid exposure in vitro induces hyperproliferation via a cyclooxygenase-2 (COX-2) dependent mechanism. Epidemiologic and animal studies suggest that COX inhibitors decrease the incidence of esophageal adenocarcinoma.Aim: To study the differential effect of complete compared with incomplete acid suppression on proliferation, apoptosis, and COX-2. Patients and
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/MCM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/Proton Pumps,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1055-9965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-93
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pubmed:dateRevised |
2010-3-23
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pubmed:meshHeading |
pubmed-meshheading:16492917-Adenocarcinoma,
pubmed-meshheading:16492917-Barrett Esophagus,
pubmed-meshheading:16492917-Caspase 3,
pubmed-meshheading:16492917-Caspases,
pubmed-meshheading:16492917-Cell Cycle Proteins,
pubmed-meshheading:16492917-Cyclooxygenase 2,
pubmed-meshheading:16492917-Enzyme Inhibitors,
pubmed-meshheading:16492917-Esophageal Neoplasms,
pubmed-meshheading:16492917-Esophagus,
pubmed-meshheading:16492917-Female,
pubmed-meshheading:16492917-Gastric Acid,
pubmed-meshheading:16492917-Histamine H2 Antagonists,
pubmed-meshheading:16492917-Humans,
pubmed-meshheading:16492917-Hydrogen-Ion Concentration,
pubmed-meshheading:16492917-Male,
pubmed-meshheading:16492917-Middle Aged,
pubmed-meshheading:16492917-Nuclear Proteins,
pubmed-meshheading:16492917-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:16492917-Proton Pumps,
pubmed-meshheading:16492917-Retrospective Studies,
pubmed-meshheading:16492917-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of acid suppression on molecular predictors for esophageal cancer.
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pubmed:affiliation |
Medical Research Council Cancer Cell Unit, Hutchison-Medical Research Council Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.
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pubmed:publicationType |
Journal Article
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