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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to countries in the tropics. Mutations in pancreatic secretory trypsin inhibitor (SPINK1) rather than cationic trypsinogen (PRSS1) explain the disease in only 50% of TCP patients. As cathepsin B (CTSB) is known to activate cationic trypsinogen, we attempted to understand the role of CTSB mutations in TCP. Evidence of epistatic interaction was investigated with the previously associated N34S SPINK1 allele, a variant considered to be a modifier rather than a true susceptibility allele. Subjects and
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1270-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16492714-Calcinosis,
pubmed-meshheading:16492714-Case-Control Studies,
pubmed-meshheading:16492714-Cathepsin B,
pubmed-meshheading:16492714-Female,
pubmed-meshheading:16492714-Gene Frequency,
pubmed-meshheading:16492714-Genetic Predisposition to Disease,
pubmed-meshheading:16492714-Haplotypes,
pubmed-meshheading:16492714-Humans,
pubmed-meshheading:16492714-Male,
pubmed-meshheading:16492714-Mutation,
pubmed-meshheading:16492714-Pancreatitis, Chronic,
pubmed-meshheading:16492714-Polymerase Chain Reaction,
pubmed-meshheading:16492714-Polymorphism, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.
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pubmed:affiliation |
Genome Research Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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