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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-2-22
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pubmed:abstractText |
Cardiovascular disease (CVD) is a major complication of Type 2 diabetes mellitus. The renin-angiotensin system (RAS) and nitric oxide production are both important regulators of vascular function and blood pressure. Genes encoding proteins involved in these pathways are candidates for a contribution to CVD in diabetic patients. We have investigated variants of the angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin type 1 receptor (AT1R) and endothelial nitric oxide synthase (NOS3) genes for association with subclinical measures of CVD in families with Type 2 diabetes mellitus (T2DM).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0742-3071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
228-34
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:16492203-Adult,
pubmed-meshheading:16492203-Aged,
pubmed-meshheading:16492203-Aged, 80 and over,
pubmed-meshheading:16492203-Angiotensinogen,
pubmed-meshheading:16492203-Atherosclerosis,
pubmed-meshheading:16492203-Cardiovascular Diseases,
pubmed-meshheading:16492203-Cohort Studies,
pubmed-meshheading:16492203-Diabetes Mellitus, Type 2,
pubmed-meshheading:16492203-Diabetic Angiopathies,
pubmed-meshheading:16492203-Endothelium,
pubmed-meshheading:16492203-Family Health,
pubmed-meshheading:16492203-Female,
pubmed-meshheading:16492203-Gene Frequency,
pubmed-meshheading:16492203-Humans,
pubmed-meshheading:16492203-Male,
pubmed-meshheading:16492203-Middle Aged,
pubmed-meshheading:16492203-Nitric Oxide Synthase,
pubmed-meshheading:16492203-Peptidyl-Dipeptidase A,
pubmed-meshheading:16492203-Polymorphism, Single Nucleotide,
pubmed-meshheading:16492203-Receptor, Angiotensin, Type 1,
pubmed-meshheading:16492203-Renin-Angiotensin System,
pubmed-meshheading:16492203-Risk Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study.
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pubmed:affiliation |
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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