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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-2-22
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pubmed:abstractText |
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/G(M2) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Hemocyanin,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Sialic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/keyhole-limpet hemocyanin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-7863
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pubmed:author |
pubmed-author:AllenJenniferJ,
pubmed-author:ChoYoung ShinYS,
pubmed-author:DanishefskySamuel JSJ,
pubmed-author:EndoAtsushiA,
pubmed-author:KedingStacy JSJ,
pubmed-author:KoideFusatakaF,
pubmed-author:LivingstonPhilip OPO,
pubmed-author:OuerfelliOuathekO,
pubmed-author:RagupathiGovindG,
pubmed-author:SpassovaMaria KMK,
pubmed-author:WanQianQ,
pubmed-author:WilsonRebecca MRM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2715-25
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16492059-Amino Acids,
pubmed-meshheading:16492059-Animals,
pubmed-meshheading:16492059-Antigens, Neoplasm,
pubmed-meshheading:16492059-Breast Neoplasms,
pubmed-meshheading:16492059-Cancer Vaccines,
pubmed-meshheading:16492059-Carbohydrate Sequence,
pubmed-meshheading:16492059-Cell Line, Tumor,
pubmed-meshheading:16492059-Female,
pubmed-meshheading:16492059-G(M2) Ganglioside,
pubmed-meshheading:16492059-Glycosides,
pubmed-meshheading:16492059-Hemocyanin,
pubmed-meshheading:16492059-Humans,
pubmed-meshheading:16492059-Male,
pubmed-meshheading:16492059-Mice,
pubmed-meshheading:16492059-Molecular Sequence Data,
pubmed-meshheading:16492059-Oligosaccharides,
pubmed-meshheading:16492059-Peptides,
pubmed-meshheading:16492059-Prostatic Neoplasms,
pubmed-meshheading:16492059-Sialic Acids
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pubmed:year |
2006
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pubmed:articleTitle |
Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.
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pubmed:affiliation |
Laboratory of Tumor Vaccinology, Clinical Immunology Service, Department of Medicine, the Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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