Linked Life Data

16490401

Source:http://linkedlifedata.com/resource/pubmed/id/16490401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-3-13
pubmed:abstractText
The wider recognition of inherited Bartter's and Bartter's-like syndromes, especially Gitelman's, has come largely as a result of the advances in, and application of, molecular genetics. By exploiting pre-existing renal cell models of ion transport, specifically for sodium and potassium, the known mechanisms and sites of action of loop and thiazide diuretics and the similarity of their chronic effects to these syndromes, it was possible for geneticists to take a candidate gene approach. This was initially successful but, when not all cases could be explained on this basis, it forced a more detailed clinical appraisal and better phenotyping, resulting in the discovery of novel genes involved in controlling renal sodium, potassium and chloride transport, and new insights into renal tubular physiology. This is a good example of one form of 'translational research', the message being the importance of our ability to link (in this instance) basic renal physiology and pharmacology, with clinical nephrology and genetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1471-4892
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
208-13
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Bartter's and Gitelman's syndromes: their relationship to the actions of loop and thiazide diuretics.
pubmed:affiliation
Centre for Nephrology and Department of Physiology, Royal Free and University College Medical School, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK. robert.unwin@ucl.ac.uk
pubmed:publicationType
Journal Article, Review