Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-4-17
pubmed:abstractText
Activated glia play a major role in mediating behavioral hypersensitive state following peripheral inflammation. Electroacupuncture is well known to relieve persistent inflammatory pain. The present study was undertaken to examine whether fluorocitrate, a glial metabolic inhibitor, could synergize electroacupuncture antagonizing thermal hyperalgesia and mechanical allodynia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articular injection of Complete Freund's Adjuvant (CFA). The paw withdrawal latency (PWL) from a thermal stimulus and paw withdrawal threshold (PWT) from von Frey hairs were measured in awake rats. Intrathecal (i.t.) injection of 1 nmol fluorocitrate markedly suppressed monoarthritis-induced thermal hyperalgesia and mechanical allodynia. Unilateral electroacupuncture stimulation of "Huantiao" (GB30) and "Yanglingquan" (GB34) acupuncture points (100/2 Hz alternation, 1-2-3 mA) significantly elevated the PWLs and PWTs for 45 min after cessation of electroacupuncture in monoarthritic rats. Co-application of 0.1 or 1 nmol fluorocitrate with electroacupuncture significantly potentiated electroacupuncture analgesia, although 0.1 nmol fluorocitrate alone had no effect on PWLs and PWTs in monoarthritic rats. These results suggested that electroacupuncture and disrupting glial function could synergistically antagonize inflammatory pain, which might provide a potential strategy for the treatment of arthritic pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-302
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16490194-Analysis of Variance, pubmed-meshheading:16490194-Animals, pubmed-meshheading:16490194-Arthritis, pubmed-meshheading:16490194-Citrates, pubmed-meshheading:16490194-Disease Models, Animal, pubmed-meshheading:16490194-Dose-Response Relationship, Drug, pubmed-meshheading:16490194-Electroacupuncture, pubmed-meshheading:16490194-Freund's Adjuvant, pubmed-meshheading:16490194-Functional Laterality, pubmed-meshheading:16490194-Hyperalgesia, pubmed-meshheading:16490194-Male, pubmed-meshheading:16490194-Neuroglia, pubmed-meshheading:16490194-Pain, pubmed-meshheading:16490194-Pain Management, pubmed-meshheading:16490194-Pain Measurement, pubmed-meshheading:16490194-Pain Threshold, pubmed-meshheading:16490194-Rats, pubmed-meshheading:16490194-Rats, Sprague-Dawley, pubmed-meshheading:16490194-Reaction Time, pubmed-meshheading:16490194-Time Factors
pubmed:year
2006
pubmed:articleTitle
Disruption of glial function enhances electroacupuncture analgesia in arthritic rats.
pubmed:affiliation
Institute of Neurobiology, Fudan University, 220 Handan Road, Shanghai 200433, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't