| pubmed-article:1648669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C0596030 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1648669 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:1648669 | pubmed:issue | 6331 | lld:pubmed |
| pubmed-article:1648669 | pubmed:dateCreated | 1991-8-15 | lld:pubmed |
| pubmed-article:1648669 | pubmed:abstractText | In many cell types, receptor activation of phosphoinositidase C results in an initial release of intracellular Ca2+ stores followed by sustained Ca2+ entry across the plasma membrane. Inositol 1,4,5-trisphosphate is the mediator of the initial Ca2+ release, although its role in the mechanism underlying Ca2+ entry remains controversial. We have now used two techniques to introduce inositol phosphates into mouse lacrimal acinar cells and measure their effects on Ca2+ entry: microinjection into cells loaded with Fura-2, a fluorescent dye which allows the measurement of intracellular free calcium concentration by microspectrofluorimetry, and perfusion of patch clamp pipettes in the whole-cell configuration while monitoring the activity of Ca(2+)-activated K+ channels as an indicator of intracellular Ca2+. We report here that inositol 1,4,5-trisphosphate serves as a signal that is both necessary and sufficient for receptor activation of Ca2+ entry across the plasma membrane in these cells. | lld:pubmed |
| pubmed-article:1648669 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1648669 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1648669 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1648669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1648669 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1648669 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:PutneyJ WJWJr | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:ArmstrongD... | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:HughesA RAR | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:ShearsS BSB | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:CIERJ FJF | lld:pubmed |
| pubmed-article:1648669 | pubmed:author | pubmed-author:RossierM FMF | lld:pubmed |
| pubmed-article:1648669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1648669 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1648669 | pubmed:volume | 352 | lld:pubmed |
| pubmed-article:1648669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1648669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1648669 | pubmed:pagination | 162-5 | lld:pubmed |
| pubmed-article:1648669 | pubmed:dateRevised | 2007-7-18 | lld:pubmed |
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| pubmed-article:1648669 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1648669 | pubmed:articleTitle | Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate. | lld:pubmed |
| pubmed-article:1648669 | pubmed:affiliation | Calcium Regulation Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709. | lld:pubmed |
| pubmed-article:1648669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1648669 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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