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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1991-8-13
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pubmed:abstractText |
We report here the identification of thyroid hormone response elements (TREs) that consist of a direct repeat, not a palindrome, of the half-sites. Unlike palindromic TREs, direct repeat TREs do not confer a retinoic acid response. The tandem TRE can be converted into a retinoic acid response element by increasing the spacing between the half-sites by 1 nucleotide, and the resulting retinoic acid response element is no longer a TRE. Decreasing the half-site spacing by 1 nucleotide converts the TRE to a vitamin D3 response element, while eliminating response to T3. These results correlate well with DNA-binding affinities of the thyroid hormone, retinoic acid, and vitamin D3 receptors. This study points to the general importance of tandem repeat hormone response elements and suggests a simple physiologic code exists in which half-site spacing plays a critical role in achieving selective hormonal response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1255-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1648450-Animals,
pubmed-meshheading:1648450-Base Sequence,
pubmed-meshheading:1648450-Binding Sites,
pubmed-meshheading:1648450-Calcitriol,
pubmed-meshheading:1648450-Carrier Proteins,
pubmed-meshheading:1648450-DNA-Binding Proteins,
pubmed-meshheading:1648450-Molecular Sequence Data,
pubmed-meshheading:1648450-Nuclear Proteins,
pubmed-meshheading:1648450-Rats,
pubmed-meshheading:1648450-Receptors, Calcitriol,
pubmed-meshheading:1648450-Receptors, Retinoic Acid,
pubmed-meshheading:1648450-Receptors, Steroid,
pubmed-meshheading:1648450-Receptors, Thyroid Hormone,
pubmed-meshheading:1648450-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1648450-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1648450-Structure-Activity Relationship,
pubmed-meshheading:1648450-Tretinoin
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pubmed:year |
1991
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pubmed:articleTitle |
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.
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pubmed:affiliation |
Gene Expression Laboratory, Howard Hughes Medical Institute, Salk Institute for Biological Studies, San Diego, California 92186-5800.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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