16484368

Source:http://linkedlifedata.com/resource/pubmed/id/16484368

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0009450, umls-concept:C0220847, umls-concept:C1515655, umls-concept:C1533691, umls-concept:C1550587
pubmed:issue	10
pubmed:dateCreated	2006-3-15
pubmed:abstractText	Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in the field has been hampered by the lack of efficient HCV culture systems. By using a recently described HCV genotype 2a infectious clone that replicates and produces infectious virus in cell culture (HCVcc), we report here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts. Importantly, virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV. The improved infectivity of animal-derived HCV correlated with virions of a lower average buoyant density than HCVcc, suggesting that physical association with low-density factors influences viral infectivity. These results greatly extend the utility of the HCVcc genetic system to allow the complete in vitro and in vivo dissection of the HCV life cycle.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI40034, http://linkedlifedata.com/resource/pubmed/grant/AI40035, http://linkedlifedata.com/resource/pubmed/grant/CA10702, http://linkedlifedata.com/resource/pubmed/grant/CA57973, http://linkedlifedata.com/resource/pubmed/grant/CA85883, http://linkedlifedata.com/resource/pubmed/grant/DK70497, http://linkedlifedata.com/resource/pubmed/grant/RR13986
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0027-8424
pubmed:author	pubmed-author:FeinstoneStephen MSM, pubmed-author:LanfordRobert ERE, pubmed-author:Leroux-RoelsGeertG, pubmed-author:LindenbachBrett DBD, pubmed-author:MajorMarian EME, pubmed-author:McKeatingJane AJA, pubmed-author:MeulemanPhilipP, pubmed-author:PlossAlexanderA, pubmed-author:RiceCharles MCM, pubmed-author:SyderAndrew JAJ, pubmed-author:VanwolleghemThomasT
pubmed:issnType	Print
pubmed:day	7
pubmed:volume	103
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3805-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:16484368-Animals, pubmed-meshheading:16484368-Chimera, pubmed-meshheading:16484368-Hepacivirus, pubmed-meshheading:16484368-Hepatitis C, pubmed-meshheading:16484368-Hepatocytes, pubmed-meshheading:16484368-Humans, pubmed-meshheading:16484368-Mice, pubmed-meshheading:16484368-Mice, SCID, pubmed-meshheading:16484368-Pan troglodytes, pubmed-meshheading:16484368-Transplantation, Heterologous, pubmed-meshheading:16484368-Virulence, pubmed-meshheading:16484368-Virus Cultivation, pubmed-meshheading:16484368-Virus Replication
pubmed:year	2006
pubmed:articleTitle	Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
pubmed:affiliation	Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
pubmed:publicationType	Journal Article, In Vitro, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural