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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6329
|
| pubmed:dateCreated |
1991-8-5
|
| pubmed:databankReference | |
| pubmed:abstractText |
Kainic acid is a potent neurotoxin for certain neurons. Its neurotoxicity is thought to be mediated by an excitatory amino-acid-gated ion channel (ionotropic receptor) possessing nanomolar affinity for kainate. Here we describe a new member of the rat excitatory amino-acid receptor gene family, KA-1, that has a 30% sequence similarity with the previously characterized alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunits GluR-A to -D. The pharmacological profile of expressed recombinant KA-1 determined in binding experiments with [3H]kainate is different from that of the cloned AMPA receptors and similar to the mammalian high-affinity kainate receptor (kainate greater than quisqualate greater than glutamate much greater than AMPA) with a dissociation constant of about 5 nM for kainate. The selectively high expression of KA-1 messenger RNA in the CA3 region of the hippocampus closely corresponds to autoradiographically located high-affinity kainate binding sites. This correlation, as well as the particular in vivo pattern of neurodegeneration observed on kainate-induced neurotoxicity, suggests that KA-1 participates in receptors mediating the kainate sensitivity of neurons in the central nervous system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
351
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
742-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1648176-Amino Acid Sequence,
pubmed-meshheading:1648176-Animals,
pubmed-meshheading:1648176-Base Sequence,
pubmed-meshheading:1648176-Binding, Competitive,
pubmed-meshheading:1648176-Brain,
pubmed-meshheading:1648176-Cell Line,
pubmed-meshheading:1648176-Cloning, Molecular,
pubmed-meshheading:1648176-Gene Expression,
pubmed-meshheading:1648176-Hippocampus,
pubmed-meshheading:1648176-Humans,
pubmed-meshheading:1648176-Kainic Acid,
pubmed-meshheading:1648176-Molecular Sequence Data,
pubmed-meshheading:1648176-RNA, Messenger,
pubmed-meshheading:1648176-Rats,
pubmed-meshheading:1648176-Receptors, Kainic Acid,
pubmed-meshheading:1648176-Receptors, Neurotransmitter,
pubmed-meshheading:1648176-Recombinant Proteins,
pubmed-meshheading:1648176-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1648176-Tissue Distribution,
pubmed-meshheading:1648176-Transfection
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells.
|
| pubmed:affiliation |
Laboratory of Molecular Neuroendocrinology, Centre for Molecular Biology, University of Heidelberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|