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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018787,
umls-concept:C0019284,
umls-concept:C0034693,
umls-concept:C0042839,
umls-concept:C0185117,
umls-concept:C0205216,
umls-concept:C0332161,
umls-concept:C1335192,
umls-concept:C1517004,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-16
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pubmed:abstractText |
Rats with nitrofen-induced congenital diaphragmatic hernia (CDH) have hypoplasia and malformations of the heart. The mechanism of action of nitrofen involves changes in neural crest signaling. Pax3 function is required for cardiac neural crest cells to complete their migration to the developing heart. Vitamin A improves heart hypoplasia. The aims of this study were to examine whether Pax3 expression is decreased in the heart of E13 E15 and E21 rats exposed to nitrofen and if vitamin A reverts this effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1531-5037
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-30
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pubmed:meshHeading |
pubmed-meshheading:16481245-Animals,
pubmed-meshheading:16481245-Animals, Newborn,
pubmed-meshheading:16481245-Hernia, Diaphragmatic,
pubmed-meshheading:16481245-Myocardium,
pubmed-meshheading:16481245-Paired Box Transcription Factors,
pubmed-meshheading:16481245-Phenyl Ethers,
pubmed-meshheading:16481245-Rats,
pubmed-meshheading:16481245-Rats, Sprague-Dawley,
pubmed-meshheading:16481245-Vitamin A
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pubmed:year |
2006
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pubmed:articleTitle |
Vitamin A improves Pax3 expression that is decreased in the heart of rats with experimental diaphragmatic hernia.
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pubmed:affiliation |
Department of Pediatric Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain.
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pubmed:publicationType |
Journal Article
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