Linked Life Data

1648061

Source:http://linkedlifedata.com/resource/pubmed/id/1648061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-6
pubmed:abstractText
With the aid of microinotophoretic techniques we tested the action of the transmitter candidate glutamate (Glu) at the afferent synapses of inner hair cells (IHC) in guinea pigs. In order to determine the various types of glutamate receptors, further agonistic excitatory amino acids (EAA) as well as competitive EAA-antagonists were used. Applied perisynaptically, Glu, aspartate, N-methyl-D-aspartate (NMDA), quisqualate (Q) and kainate (K) activate the subsynaptic, phasic firing activity of the afferent dendrites. The NMDA-induced activation is augmented by simultaneous application of glycine. The firing rate induced by Glu and NMDA is blocked by the specific NMDA-antagonist D-2-amino-7-phosphonoheptanoate (AP-7). Furthermore, activity induced by Glu and Q decreases under the influence of the selective Q-antagonist glutamic acid diethylester (GDEE). These results are consistent with the hypothesis that Glu acts as a possible afferent neurotransmitter of the IHC. This neurotransmission is mediated by postsynaptic EAA-receptor subpopulations which are sensitive to NMDA, Q and K. The activity of the NMDA-receptors depends, however, on the amount of glycine available. Our data suggest that the afferent synapses of the IHC possess functional properties which are equivalent to the properties of glutamatergic NMDA-sensitive and NMDA-non-sensitive synapses in the central nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Glutamate receptors in afferent cochlear neurotransmission in guinea pigs.
pubmed:affiliation
First ENT Department, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't