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pubmed-article:16480348pubmed:abstractTextPatient-controlled sedation (PCS) allows patients to match their sedation requirement to perceived discomfort. The significant delay in onset of sedation may be overcome with effect-site steered target controlled infusion, but previously only trials in volunteers have been carried out. We therefore conducted a randomised, double-blind controlled trial comparing effect-site steered propofol PCS with anaesthetist-administered propofol sedation in 40 patients presenting for colonoscopy. The initial effect-site target in the PCS group was 0.8 microg.ml(-1), increment was 0.1 microg.ml(-1) and lockout was 3 min. Patient and endoscopist satisfaction and operating conditions were similar between the two groups. PCS patients were sedated more slowly (13 [7.1] vs. 3 [1.1] min; p < 0.0001) and less deeply (minimum BIS value: 71 [16] vs. 58 [15]; p = 0.13) than anaesthetist-administered propofol sedation patients. More of the latter patients were hypotensive, but all patients had similar recollection of events during the procedure and similar quality of recovery.lld:pubmed
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pubmed-article:16480348pubmed:authorpubmed-author:LeslieKKlld:pubmed
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pubmed-article:16480348pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16480348pubmed:year2006lld:pubmed
pubmed-article:16480348pubmed:articleTitleEffect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy.lld:pubmed
pubmed-article:16480348pubmed:affiliationResearch Fellow, 2 Head of Research, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Australia.lld:pubmed
pubmed-article:16480348pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16480348pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16480348pubmed:publicationTypeRandomized Controlled Triallld:pubmed
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