Source:http://linkedlifedata.com/resource/pubmed/id/16480348
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2006-2-16
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pubmed:abstractText |
Patient-controlled sedation (PCS) allows patients to match their sedation requirement to perceived discomfort. The significant delay in onset of sedation may be overcome with effect-site steered target controlled infusion, but previously only trials in volunteers have been carried out. We therefore conducted a randomised, double-blind controlled trial comparing effect-site steered propofol PCS with anaesthetist-administered propofol sedation in 40 patients presenting for colonoscopy. The initial effect-site target in the PCS group was 0.8 microg.ml(-1), increment was 0.1 microg.ml(-1) and lockout was 3 min. Patient and endoscopist satisfaction and operating conditions were similar between the two groups. PCS patients were sedated more slowly (13 [7.1] vs. 3 [1.1] min; p < 0.0001) and less deeply (minimum BIS value: 71 [16] vs. 58 [15]; p = 0.13) than anaesthetist-administered propofol sedation patients. More of the latter patients were hypotensive, but all patients had similar recollection of events during the procedure and similar quality of recovery.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-2409
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16480348-Adolescent,
pubmed-meshheading:16480348-Adult,
pubmed-meshheading:16480348-Aged,
pubmed-meshheading:16480348-Colonoscopy,
pubmed-meshheading:16480348-Conscious Sedation,
pubmed-meshheading:16480348-Consciousness,
pubmed-meshheading:16480348-Double-Blind Method,
pubmed-meshheading:16480348-Drug Administration Schedule,
pubmed-meshheading:16480348-Female,
pubmed-meshheading:16480348-Humans,
pubmed-meshheading:16480348-Hypnotics and Sedatives,
pubmed-meshheading:16480348-Male,
pubmed-meshheading:16480348-Middle Aged,
pubmed-meshheading:16480348-Pain Measurement,
pubmed-meshheading:16480348-Patient Satisfaction,
pubmed-meshheading:16480348-Propofol,
pubmed-meshheading:16480348-Self Administration
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pubmed:year |
2006
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pubmed:articleTitle |
Effect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy.
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pubmed:affiliation |
Research Fellow, 2 Head of Research, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial
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