Linked Life Data

16480061

Source:http://linkedlifedata.com/resource/pubmed/id/16480061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-2-16
pubmed:abstractText
A low protein diet(LPD) has been prescribed to alleviate uremic symptoms, and to delay the aggravation of chronic renal failure(CRF). However, it has been suggested that LPD treatment causes malnutrition and attenuation of muscle power. On the other hand, it also has been suggested that appropriate long-term exercise training(EX) may lead to improvement of the physical fitness and quality of life (QOL) in patients with CRF. However, there is no definitive conclusion as to whether EX has any renal protective effect or not. We assessed the effects of combination therapy with LPD and EX. We also assessed the effects of a combination of these therapies and the angiotensin II receptor antagonist, olmesartan (OLS). Male Wistar Kyoto rats that were five-sixth-nephrectomized were divided into 6 groups; 1) normal-protein diet(NPD); 2) NPD and EX with treadmill running(1 h/day, 5 days/week for 12 weeks)(NPD + EX); 3) LPD; 4) LPD + EX; 5) LPD + EX with OLS( 10 mg/kg/day for 12 weeks) (LPD + EX + OLS); and 6) Sham-operated(S). Systolic blood pressure(SBP) in the NPD + EX, LPD + EX, LPD + EX + OLS, and S groups was significantly lower than in the NPD group. Moreover, SBP in the LPD + EX + OLS was significantly lower than in all the other groups. LPD, LPD + EX, and LPD + EX + OLS induced a significant decrease in UP, Scr and BUN compared with the NPD group. UP in the LPD + EX, LPD + EX + OLS, and S groups was significantly lower than in the LPD group. The index of glomerular sclerosis (IGS) and relative interstitial volume(RIV) in the NPD + EX, LPD, LPD + EX, LPD + EX + OLS, and S groups were significantly lower than the values in the NPD group. IGS and RIV in the LPD, LPD + EX, LPD + EX + OLS, and S groups were significantly lower than the values in the NPD + EX and LPD groups. Glomerular ED-1 positive cells in the LPD + EX, LPD + EX + OLS, and S groups was significantly fewer than in the NPD groups. These results indicate that LPD and EX have renoprotective effects, and suggest that the combination therapy with LPD and EX provides greater renoprotective effects than LPD alone. Moreover simultaneous treatment of OLS and LPD + EX provides greater antihypertensive and antiproteinuric effects than treatment with LPD + EX.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0385-2385
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4-13
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Renoprotective and antihypertensive effect of combination therapy with a low protein diet, long-term exercise and angiotensin II receptor antagonist in rats with renal ablation].
pubmed:affiliation
Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Miyagi, Japan.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't