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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1991-8-6
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pubmed:abstractText |
We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
24
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1647983-Amino Acid Sequence,
pubmed-meshheading:1647983-Animals,
pubmed-meshheading:1647983-Brain Chemistry,
pubmed-meshheading:1647983-Macromolecular Substances,
pubmed-meshheading:1647983-Male,
pubmed-meshheading:1647983-Mice,
pubmed-meshheading:1647983-Molecular Sequence Data,
pubmed-meshheading:1647983-Nucleic Acid Hybridization,
pubmed-meshheading:1647983-Polymerase Chain Reaction,
pubmed-meshheading:1647983-RNA, Messenger,
pubmed-meshheading:1647983-Receptors, GABA-A,
pubmed-meshheading:1647983-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1647983-Tissue Distribution
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pubmed:year |
1991
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pubmed:articleTitle |
A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction.
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pubmed:affiliation |
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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