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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-2-15
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pubmed:abstractText |
Telomerase adds telomeric repeats to the ends of telomeres to compensate for their progressive loss. A favorable prognosis is associated with low or no telomerase in some tumors. The authors investigated whether telomerase activity is associated with survival of patients with brain tumors. Sixty-two consecutive patients with brain tumors underwent surgery, and their surgical specimens were investigated. The patients were pathologically categorized as group I (aggressive group) and group II (non-aggressive group). Telomerase activity was examined by the telomeric repeat amplification protocol (TRAP) assay. The median time was calculated in association with overall survival and progression-free survival in each group. The significant difference was noted in telomerase activity between high-grade gliomas and lowgrade gliomas (p=0.022). Telomerase activity was significantly associated with the median overall survival and progression-free survival in all tumors of the aggressive group. On the other hand, the median overall survival in the non-aggressive group was not dependent on telomerase activity, while the median progression-free survival was. Our data suggests that telomerase is an important prognostic indicator of survival in patients with brain tumors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-10449030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-10491533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-10917055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-11107139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-11981616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-12825819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-12871779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-15162351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-1708110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-2342578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-3907856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-7605428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-8159672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9020079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9389643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9419332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9605755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9750021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16479078-9879692
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1011-8934
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16479078-Adolescent,
pubmed-meshheading:16479078-Adult,
pubmed-meshheading:16479078-Aged,
pubmed-meshheading:16479078-Brain Neoplasms,
pubmed-meshheading:16479078-Child,
pubmed-meshheading:16479078-Child, Preschool,
pubmed-meshheading:16479078-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16479078-Female,
pubmed-meshheading:16479078-Humans,
pubmed-meshheading:16479078-Male,
pubmed-meshheading:16479078-Middle Aged,
pubmed-meshheading:16479078-Polymerase Chain Reaction,
pubmed-meshheading:16479078-Prognosis,
pubmed-meshheading:16479078-Survival Analysis,
pubmed-meshheading:16479078-Telomerase
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pubmed:year |
2006
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pubmed:articleTitle |
Prognostic implication of telomerase activity in patients with brain tumors.
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pubmed:affiliation |
Department of Neurosurgery, Hanyang University College of Medicine, Seoul, Korea. kch5142@hanyang.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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