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pubmed-article:16476504pubmed:abstractTextOnly few studies have compared the agreement of histological lung carcinoma diagnosis of a population-based case series and an independent pathology review. We analyzed data of our population-based lung cancer case-control study to determine the agreement in the histopathological evaluation of lung cancer. Six-hundred and sixty-eight out of 1004 interviewed male and female lung cancer cases were histologically evaluated according to the 1981 WHO classification by regional pathologists and a central pathologist who was blinded to the evaluations of the regional pathologists. The observed agreement was 0.65 with kappa = 0.54 (95% CI: 0.49-0.58). It was highest for small-cell carcinoma (0.94; kappa = 0.82) and lower for squamous-cell carcinoma (0.81; kappa = 0.58) and adenocarcinoma (0.81; kappa = 0.55). Agreement was slightly higher among women than men. The observed agreement among non-smoking cases was 58% as compared to 67% heavy smoking cases. The moderate agreement for squamous-cell and adenocarcinoma complicates epidemiological studies that address these histological subtypes.lld:pubmed
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pubmed-article:16476504pubmed:year2006lld:pubmed
pubmed-article:16476504pubmed:articleTitleDiagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study.lld:pubmed
pubmed-article:16476504pubmed:affiliationInstitute of Medical Epidemiology, Biometry and Informatics, Medical Faculty, Martin-Luther-University of Halle-Wittenberg, Magdeburger Str. 27, 06097 Halle, Germany. andreas.stang@medizin.uni-halle.delld:pubmed
pubmed-article:16476504pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16476504pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16476504pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16476504pubmed:publicationTypeMulticenter Studylld:pubmed
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