Source:http://linkedlifedata.com/resource/pubmed/id/16476010
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-2-14
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| pubmed:abstractText |
We have reported previously that subclinical prolonged mild T helper (Th) 1-dependent autoimmune insulitis with impaired glucose tolerance in wealing DBA/1J mice, which is induced by the combined effects of reovirus type 2 (Reo-2) and synthetic 20-base oligodeoxynucleotides with CpG motifs (CpG ODN) (control mice). Compared with the control mice, newborn mice treated with monoclonal antibody (MoAb) against mouse CD25(+) CD4(+) T cells together with Reo-2 and CpG ODN greatly reduced the absolute number of splenic CD25(+) T cells and resulted in the development of severe insulitis, leading to an overt early diabetes. Moreover, the treatment of the MoAb increased production of interferon-gamma (IFN-gamma) and decreased that of interleukin-4 (IL-4) and transforming growth factor-beta1 (TGF-beta1) and developed high titre of autoantibodies against pancreatic islet cells. These evidences suggest that CD4(+) CD25(+) T cell may, at least in part, maintain tolerance to Reo-2-triggered and CpG ODN-induced prolonged mild Th1-dependent autoimmune insulitis, leading to the overt disease. This system may give a novel model to elucidate the mechanisms of the development of overt diabetes from borderline subclinical diabetes in virus-triggered autoimmune type I diabetes in human.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0300-9475
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
63
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
116-24
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| pubmed:dateRevised |
2009-9-28
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| pubmed:meshHeading |
pubmed-meshheading:16476010-Animals,
pubmed-meshheading:16476010-Animals, Newborn,
pubmed-meshheading:16476010-Antibodies, Monoclonal,
pubmed-meshheading:16476010-Antigens, Viral,
pubmed-meshheading:16476010-Blood Glucose,
pubmed-meshheading:16476010-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16476010-CpG Islands,
pubmed-meshheading:16476010-Cytokines,
pubmed-meshheading:16476010-Diabetes Mellitus, Type 2,
pubmed-meshheading:16476010-Female,
pubmed-meshheading:16476010-Glucose Tolerance Test,
pubmed-meshheading:16476010-Histocytochemistry,
pubmed-meshheading:16476010-Male,
pubmed-meshheading:16476010-Mice,
pubmed-meshheading:16476010-Mice, Inbred DBA,
pubmed-meshheading:16476010-Oligonucleotides,
pubmed-meshheading:16476010-Orthoreovirus, Mammalian,
pubmed-meshheading:16476010-Pancreas,
pubmed-meshheading:16476010-Receptors, Interleukin-2,
pubmed-meshheading:16476010-Reoviridae Infections,
pubmed-meshheading:16476010-Spleen
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| pubmed:year |
2006
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| pubmed:articleTitle |
Elimination of CD4+ CD25+ regulatory T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice.
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| pubmed:affiliation |
Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Yamaguchi, Japan. hayasi@yamaguchi-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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