Source:http://linkedlifedata.com/resource/pubmed/id/16475702
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1A
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pubmed:dateCreated |
2006-2-14
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pubmed:abstractText |
Enhanced garlic (Allium sativum) consumption is closely related to reduced cancer incidence, as shown in epidemiological studies. Diallyl disulfide (DADS), a component of garlic, inhibits the proliferation of human blood, colon, lung and skin cancer cells. Although DADS had been reported to induce apoptosis in human leukemia HL-60 cells, there are no reports regarding whether or not it affects leukemia cells in vivo. Therefore, the present study is focused on the in vivo effects of DADS on WEHI-3 leukemia cells. The effects of DADS on murine WEHI-3 cells were initially examined, and the results indicated that DADS induced cytotoxicity and that this effect was dose-dependent. The effects of DADS on WEHI-3 in BALBIc mice were also examined, and the results indicated that DADS decreased the percentage of MAC-3 marker, indicating that differentiation of the precursor of macrophage and T cells was inhibited. The weights of liver and spleen were also measured, and the results indicated that DADS decreased the weight of these organs. An important characteristic of WEHI-3 leukemia is the enlarged spleen in mice after i.p. injection of WEHI-3 cells. Based on pathological examination, the function of DADS was observed in the liver and spleen of mice previously injected with WEHI-3 cells. Apparently, DADS affects WEHI-3 cells both in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
pubmed-author:ChenGuang-WeiGW,
pubmed-author:ChungJing-GungJG,
pubmed-author:HoHeng-ChienHC,
pubmed-author:HuangWen-WenWW,
pubmed-author:KokLai-FongLF,
pubmed-author:KuoTzu-ChingTC,
pubmed-author:LinChin-ChungCC,
pubmed-author:LinYu-HsuanYH,
pubmed-author:YangJai-SingJS,
pubmed-author:YangJiun-LongJL
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16475702-Allyl Compounds,
pubmed-meshheading:16475702-Animals,
pubmed-meshheading:16475702-Antineoplastic Agents,
pubmed-meshheading:16475702-Cell Growth Processes,
pubmed-meshheading:16475702-Cell Line, Tumor,
pubmed-meshheading:16475702-Disulfides,
pubmed-meshheading:16475702-Leukemia, Myeloid,
pubmed-meshheading:16475702-Liver,
pubmed-meshheading:16475702-Male,
pubmed-meshheading:16475702-Mice,
pubmed-meshheading:16475702-Mice, Inbred BALB C,
pubmed-meshheading:16475702-Organ Size,
pubmed-meshheading:16475702-Spleen
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pubmed:articleTitle |
Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo.
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pubmed:affiliation |
Department of Medical Technology Yuan-Pei University of Science and Technology, Hsinchu, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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