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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-20
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pubmed:abstractText |
We recently reported that activated normal human B lymphocytes express Cox-2. These findings prompted us to evaluate whether human B-CLL cells express Cox-2 and synthesize prostaglandins. In contrast to naive human B cells, B-CLL cells constitutively expressed Cox-2 protein and produced PGE2, PGF2alpha, and TXA2. Elevated Cox-2 expression was seen in a subgroup of B-CLL cells that exhibit poor prognostic factors, including unmutated variable heavy chain status and increased CD38 expression. Furthermore, stimulation of B-CLL cells with CD40 ligand plus TNFalpha increased Cox-2 levels. The role of Cox-2 in promoting B-CLL survival was investigated using nonselective and selective Cox-2 inhibitors. Significant reductions in B-CLL survival occurred following Cox-2 inhibition. These new findings support that constitutive Cox-2 expression in B-CLL cells promotes their survival and possibly their expansion in vivo. It will therefore be important to evaluate drugs that inhibit Cox-2 as potential therapeutic agents in B-CLL in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-((4-methylsulfonyl)phenyl)-3-trifl...,
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-methylsulfonylphenyl)-4-phenyl-...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1521-6616
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
76-90
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16473553-B-Lymphocytes,
pubmed-meshheading:16473553-Cell Growth Processes,
pubmed-meshheading:16473553-Cyclooxygenase 1,
pubmed-meshheading:16473553-Cyclooxygenase 2,
pubmed-meshheading:16473553-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:16473553-Dinoprost,
pubmed-meshheading:16473553-Dinoprostone,
pubmed-meshheading:16473553-Enzyme Activation,
pubmed-meshheading:16473553-Humans,
pubmed-meshheading:16473553-Immunoglobulin Heavy Chains,
pubmed-meshheading:16473553-Immunohistochemistry,
pubmed-meshheading:16473553-Indomethacin,
pubmed-meshheading:16473553-Isoxazoles,
pubmed-meshheading:16473553-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16473553-Nitrobenzenes,
pubmed-meshheading:16473553-Pyrazoles,
pubmed-meshheading:16473553-Sulfonamides,
pubmed-meshheading:16473553-Sulfones,
pubmed-meshheading:16473553-Thromboxane A2
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pubmed:year |
2006
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pubmed:articleTitle |
Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
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pubmed:affiliation |
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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