Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-3-13
pubmed:abstractText
Behavioral evidence supports a role for peripheral glutamate receptors in normal nociceptive transmission. In this study, we examined the release of the excitatory amino acids, glutamate and aspartate, in the s.c. perfusate of the rat hind instep by in vivo microdialysis. Antidromic stimulation of the sciatic nerve and noxious stimuli in the form of heat stimulation and local application of capsaicin cream (1%) to the instep caused an increase in excitatory amino acid release. This capsaicin-induced excitatory amino acid release was suppressed by pretreatment with capsaicin. Both systemic (10 mg/kg, i.v.) and local injections (10(-5) M in the perfusate) of morphine inhibited the increase in excitatory amino acid release evoked by local application of capsaicin cream to the instep. This inhibitory effect of morphine was antagonized by naloxone either given systemically (5 mg/kg, i.v.) or locally (10(-5) M). These results suggest that excitatory amino acids are released from small diameter afferent fibers by heat stimulation in the periphery or local application of capsaicin cream, and that activation of opioid receptors, present on the peripheral endings of small-diameter afferent fibers, can regulate noxious stimulus-induced excitatory amino acid release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1329-39
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16473472-Analgesics, Opioid, pubmed-meshheading:16473472-Animals, pubmed-meshheading:16473472-Aspartic Acid, pubmed-meshheading:16473472-Capsaicin, pubmed-meshheading:16473472-Disease Models, Animal, pubmed-meshheading:16473472-Drug Interactions, pubmed-meshheading:16473472-Electric Stimulation, pubmed-meshheading:16473472-Glutamic Acid, pubmed-meshheading:16473472-Hot Temperature, pubmed-meshheading:16473472-Male, pubmed-meshheading:16473472-Morphine, pubmed-meshheading:16473472-Narcotic Antagonists, pubmed-meshheading:16473472-Nerve Fibers, Unmyelinated, pubmed-meshheading:16473472-Neural Conduction, pubmed-meshheading:16473472-Nociceptors, pubmed-meshheading:16473472-Opioid Peptides, pubmed-meshheading:16473472-Pain, pubmed-meshheading:16473472-Pain Threshold, pubmed-meshheading:16473472-Rats, pubmed-meshheading:16473472-Rats, Sprague-Dawley, pubmed-meshheading:16473472-Receptors, Glutamate, pubmed-meshheading:16473472-Receptors, Opioid, pubmed-meshheading:16473472-Sensory Receptor Cells, pubmed-meshheading:16473472-Signal Transduction
pubmed:year
2006
pubmed:articleTitle
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
pubmed:affiliation
Department of Pharmacology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
pubmed:publicationType
Journal Article