Linked Life Data

1647291

Source:http://linkedlifedata.com/resource/pubmed/id/1647291

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-8-1
pubmed:abstractText
The influences of different calcium concentrations in the culture medium on in vitro growth kinetics (generation time and saturation density) of established human colonic mucosal lines derived from subjects with and without familial adenomatosis of the colon and rectum were studied to test the hypothesis that hyperproliferation of colonic mucosal cells observed in some familial colon cancer can be reversed by increased extracellular calcium concentration. From the present studies, the genomic source of the adenomatous colonic lines appear to modify the effect of increased calcium on mucosal growth as demonstrated by differences in growth response in lines with and without the biomarker associated with genetic predisposition for some colon cancers, increased in vitro tetraploidy. Such observations suggested that other factors, including genomic differences, should be taken into consideration in the determination of the possible influences of calcium concentration on colonic mucosal proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0012-3706
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
552-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effect of increased calcium concentration on in vitro growth of human colonic mucosal lines.
pubmed:affiliation
Department of Medicine, Cornell University Medical College, New York, New York.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't