Linked Life Data

1647267

Source:http://linkedlifedata.com/resource/pubmed/id/1647267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1991-8-1
pubmed:abstractText
Here the adeno-associated virus Rep78 gene product was found to inhibit the expression of the chloramphenicol acetyltransferase and the bladder cancer-derived EJ-H-ras coding sequences when they were under the control of the natural cellular H-ras regulatory sequences. However, Rep78 had little or no effect on the expression of these same coding sequences when they were under the control of the regulatory sequences of the murine osteosarcoma virus long terminal repeat. These data indicate that the inhibition of H-ras by Rep78 depends upon sequences present within the cellular H-ras upstream regulatory region. Furthermore, these and earlier data indicate that Rep78 functions as an "antioncogene" or transformation suppressor gene, inhibiting H-ras as well as several viral oncogenes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
51
pubmed:geneSymbol
HRAS, Rep78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3373-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock 72205.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't