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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-13
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pubmed:abstractText |
The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this study was to investigate the association of functional polymorphisms of the PXR encoding gene (NR1I2) with disease in IBD populations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:BrophyKaren MKM,
pubmed-author:DringMegan MMM,
pubmed-author:GouldingCarol ACA,
pubmed-author:KeeganDeniseD,
pubmed-author:KeelingP W NapoleonPW,
pubmed-author:KelleherDermotD,
pubmed-author:MahmudNasirN,
pubmed-author:McManusRossR,
pubmed-author:O'DonoghueDiarmuidD,
pubmed-author:O'MorainColmC,
pubmed-author:O'SullivanMariaM,
pubmed-author:RyanAnthony WAW,
pubmed-author:SmythClaire MCM,
pubmed-author:TrimbleValerie IVI,
pubmed-author:WikströmAnn-CharlotteAC
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-8; quiz 592
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16472590-Colitis, Ulcerative,
pubmed-meshheading:16472590-Crohn Disease,
pubmed-meshheading:16472590-Gene Expression Regulation,
pubmed-meshheading:16472590-Genetic Variation,
pubmed-meshheading:16472590-Genotype,
pubmed-meshheading:16472590-Humans,
pubmed-meshheading:16472590-Inflammatory Bowel Diseases,
pubmed-meshheading:16472590-Ireland,
pubmed-meshheading:16472590-Odds Ratio,
pubmed-meshheading:16472590-Polymorphism, Single Nucleotide,
pubmed-meshheading:16472590-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:16472590-Receptors, Steroid,
pubmed-meshheading:16472590-Reference Values
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pubmed:year |
2006
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pubmed:articleTitle |
The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.
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pubmed:affiliation |
Department of Clinical Medicine, Trinity Centre for Health Science, St James's Hospital, Dublin.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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