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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-8-1
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pubmed:abstractText |
To define relations between trophic molecules and known sexually dimorphic traits in brain, we examined possible sex differences in nerve growth factor (NGF) and NGF receptor (NGF-R) gene expression in the rat cholinergic basal forebrain (BF)-hippocampal system. Hippocampal NGF mRNA levels did not differ between sexes; in contrast, BF NGF-R mRNA levels were greater in neonatal females than males, paralleling the known dimorphic development of cholinergic enzyme activity. Cerebellar NGF-R mRNA levels were also dimorphic in the neonate, suggesting that sex-specific influences may regulate trophic receptor gene expression in diverse brain systems.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
542
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1647253-Animals,
pubmed-meshheading:1647253-Brain,
pubmed-meshheading:1647253-Female,
pubmed-meshheading:1647253-Gene Expression Regulation,
pubmed-meshheading:1647253-Hippocampus,
pubmed-meshheading:1647253-Male,
pubmed-meshheading:1647253-Nerve Growth Factors,
pubmed-meshheading:1647253-RNA, Messenger,
pubmed-meshheading:1647253-Rats,
pubmed-meshheading:1647253-Receptors, Cell Surface,
pubmed-meshheading:1647253-Receptors, Nerve Growth Factor,
pubmed-meshheading:1647253-Sex Characteristics
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pubmed:year |
1991
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pubmed:articleTitle |
Sexually dimorphic expression of the NGF receptor gene in the developing rat brain.
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pubmed:affiliation |
Department of Neurology, Cornell University Medical College, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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