|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1991-7-29
|
|
pubmed:abstractText |
We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free platelet [3H]-imipramine binding and brain MRI studies were obtained during the same episode of depression. Our findings show a significant inverse relationship between frequency of subcortical hyperintensity (SCH) and the number (Bmax) of platelet [3H]-imipramine binding sites. Patients with Bmax less than 850 fmol/mg protein had significantly larger SCH compared with patients with a higher Bmax. These data provide further support to the potential use of platelet [3H]-imipramine binding studies and brain MR imaging as diagnostic adjuncts in geriatric depression and suggest, moreover, that these two biological markers may be linked in geriatric patients with depression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-3223
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
665-70
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:1647227-Aged,
pubmed-meshheading:1647227-Aged, 80 and over,
pubmed-meshheading:1647227-Blood Platelets,
pubmed-meshheading:1647227-Brain,
pubmed-meshheading:1647227-Carrier Proteins,
pubmed-meshheading:1647227-Dementia,
pubmed-meshheading:1647227-Depressive Disorder,
pubmed-meshheading:1647227-Female,
pubmed-meshheading:1647227-Humans,
pubmed-meshheading:1647227-Imipramine,
pubmed-meshheading:1647227-Leukoencephalopathy, Progressive Multifocal,
pubmed-meshheading:1647227-Magnetic Resonance Imaging,
pubmed-meshheading:1647227-Male,
pubmed-meshheading:1647227-Middle Aged,
pubmed-meshheading:1647227-Receptors, Drug,
pubmed-meshheading:1647227-Receptors, Neurotransmitter
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.
|
|
pubmed:affiliation |
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
