Linked Life Data

1647128

Source:http://linkedlifedata.com/resource/pubmed/id/1647128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-7-24
pubmed:abstractText
The effects of the H3 agonist (R) alpha-methyl histamine ( (R) alpha-MeHA) on the isolated guinea pig aorta were investigated. At all the concentrations of (R) alpha-MeHA used, a relaxation of the aorta, which had been preconstricted with KC1 (50mM), was produced. This response was abolished by the H3 antagonist mixture of cimetidine (100 microM) and impromidine (10 microM). In contrast the same concentrations of histamine produced vasoconstriction which could be abolished by the H1 antagonist pyrilamine (3 microM). The results show that (R) alpha-MeHA produces a vasodilation response which is most probably mediated by H3 receptors and provides further evidence of a functional role for H3 receptors in the control of the cardiovascular system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-0363
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta.
pubmed:affiliation
Sherrington School of Physiology, UMDS, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't