|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1991-7-19
|
|
pubmed:abstractText |
Nerve growth factor (NGF) in the mouse submandibular gland undergoes cleavage of its amino-terminal octapeptide when salivation is induced by epinephrine. The significance of this event is uncertain; cleaved NGF demonstrates bioactivity and no function has been attributed to the octapeptide produced (NGF-OP; Ser-Ser-Thr-His-Pro-Val-Phe-His). Enzyme inhibition studies indicating structural relatedness of NGF-OP and bradykinin (BK) prompted us to determine whether NGF-OP would elicit BK-like actions. We found that like BK, NGF-OP induced a decrease in mechanical nociceptive threshold (i.e., produced hyperalgesia) in the hairy skin of the rat. This effect was dose-dependent and sequence-specific; like BK it was attenuated by sympathectomy and indomethacin pretreatment. However, NGF-OP actions appeared to be distinct from those for BK in that tissue injury was required for NGF-OP to induce hyperalgesia. Furthermore, we found no evidence that NGF-OP bound to or activated BK receptors. Our data indicate that NGF-OP is a distinct mediator of hyperalgesia. We suggest that NGF-OP alters pain threshold in the injured target regions of NGF-responsive neurons.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-1004630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-110805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-1148872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-1206401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-186790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2427334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2537408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2581648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-267927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2697237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2823989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2825206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2894457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-2902216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3012551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3034917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3061568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3090553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3306916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3317065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3323396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3342935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3625240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3742234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3748187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3840547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-3961484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-4146573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-4430560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-4777497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-6132853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-6254391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-6407016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-701289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-7015371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1647026-999827
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
88
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5144-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1647026-Animals,
pubmed-meshheading:1647026-Bradykinin,
pubmed-meshheading:1647026-Hyperalgesia,
pubmed-meshheading:1647026-Male,
pubmed-meshheading:1647026-Nerve Growth Factors,
pubmed-meshheading:1647026-Pain,
pubmed-meshheading:1647026-Peptides,
pubmed-meshheading:1647026-Rats,
pubmed-meshheading:1647026-Rats, Inbred Strains,
pubmed-meshheading:1647026-Receptors, Bradykinin,
pubmed-meshheading:1647026-Receptors, Neurotransmitter,
pubmed-meshheading:1647026-Sensory Thresholds
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
|
|
pubmed:affiliation |
Neuroscience Program, University of California, School of Medicine, San Francisco 94143.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
