| pubmed-article:16469432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C2350570 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C1134719 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C1512084 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C0746319 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C0178587 | lld:lifeskim |
| pubmed-article:16469432 | lifeskim:mentions | umls-concept:C1517564 | lld:lifeskim |
| pubmed-article:16469432 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16469432 | pubmed:dateCreated | 2006-10-9 | lld:pubmed |
| pubmed-article:16469432 | pubmed:abstractText | The aim of this study is to investigate the possible role of inhibitor of DNA binding (Id-1) overexpression in human breast cancer. We examined Id-1 expression by immunohistochemistry in 263 human breast cancers, 15 in situ lesions and 248 invasive cancers to investigate the relationship between its expression and various clinicopathological factors. Id-1 expression was significantly higher in invasive ductal carcinoma than in in situ ductal carcinoma or other invasive cancer subtypes (P=0.029 and 0.006, respectively). We also examined the association between Id-1 expression and tumor angiogenesis by measuring microvessel densities (MVD). Regarding the endothelial cells of microvessels showed negative or very weak Id-1 expression, Id-1 overexpression was found to be significantly related to MVD (P=0.014). Furthermore, Id-1 overexpression was found to be significantly associated with higher MVD in the ER-negative and node-involved subgroups of breast cancer (P=0.040 and 0.046, respectively). These data indicate that Id-1 overexpression is significantly associated with tumor angiogenesis, especially in the ER-negative and node-positive subtypes of invasive breast cancer. Thus, Id-1 presents a possible therapeutic antitumor target molecule in ER-negative and node-positive breast cancer. | lld:pubmed |
| pubmed-article:16469432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16469432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16469432 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16469432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16469432 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16469432 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:16469432 | pubmed:author | pubmed-author:BrownPowel... | lld:pubmed |
| pubmed-article:16469432 | pubmed:author | pubmed-author:KongGuG | lld:pubmed |
| pubmed-article:16469432 | pubmed:author | pubmed-author:PaikSeung... | lld:pubmed |
| pubmed-article:16469432 | pubmed:author | pubmed-author:HanHong XiuHX | lld:pubmed |
| pubmed-article:16469432 | pubmed:author | pubmed-author:JangKi-SeokKS | lld:pubmed |
| pubmed-article:16469432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16469432 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:16469432 | pubmed:volume | 244 | lld:pubmed |
| pubmed-article:16469432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16469432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16469432 | pubmed:pagination | 203-10 | lld:pubmed |
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| pubmed-article:16469432 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16469432 | pubmed:articleTitle | Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer. | lld:pubmed |
| pubmed-article:16469432 | pubmed:affiliation | Department of Pathology, College of Medicine, Hanyang University, 17 Haengdang-dang, Seongdong-Gu, Seoul 133-791, South Korea. | lld:pubmed |
| pubmed-article:16469432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16469432 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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