Source:http://linkedlifedata.com/resource/pubmed/id/16469432
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-10-9
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| pubmed:abstractText |
The aim of this study is to investigate the possible role of inhibitor of DNA binding (Id-1) overexpression in human breast cancer. We examined Id-1 expression by immunohistochemistry in 263 human breast cancers, 15 in situ lesions and 248 invasive cancers to investigate the relationship between its expression and various clinicopathological factors. Id-1 expression was significantly higher in invasive ductal carcinoma than in in situ ductal carcinoma or other invasive cancer subtypes (P=0.029 and 0.006, respectively). We also examined the association between Id-1 expression and tumor angiogenesis by measuring microvessel densities (MVD). Regarding the endothelial cells of microvessels showed negative or very weak Id-1 expression, Id-1 overexpression was found to be significantly related to MVD (P=0.014). Furthermore, Id-1 overexpression was found to be significantly associated with higher MVD in the ER-negative and node-involved subgroups of breast cancer (P=0.040 and 0.046, respectively). These data indicate that Id-1 overexpression is significantly associated with tumor angiogenesis, especially in the ER-negative and node-positive subtypes of invasive breast cancer. Thus, Id-1 presents a possible therapeutic antitumor target molecule in ER-negative and node-positive breast cancer.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ID1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0304-3835
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
8
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| pubmed:volume |
244
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
203-10
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| pubmed:meshHeading |
pubmed-meshheading:16469432-Adenocarcinoma,
pubmed-meshheading:16469432-Breast Neoplasms,
pubmed-meshheading:16469432-Carcinoma, Ductal, Breast,
pubmed-meshheading:16469432-Female,
pubmed-meshheading:16469432-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16469432-Humans,
pubmed-meshheading:16469432-Immunoenzyme Techniques,
pubmed-meshheading:16469432-Inhibitor of Differentiation Protein 1,
pubmed-meshheading:16469432-Lymph Nodes,
pubmed-meshheading:16469432-Microcirculation,
pubmed-meshheading:16469432-Middle Aged,
pubmed-meshheading:16469432-Neoplasm Invasiveness,
pubmed-meshheading:16469432-Neoplasm Staging,
pubmed-meshheading:16469432-Neoplasms, Ductal, Lobular, and Medullary,
pubmed-meshheading:16469432-Neovascularization, Pathologic,
pubmed-meshheading:16469432-Prognosis,
pubmed-meshheading:16469432-Receptors, Estrogen,
pubmed-meshheading:16469432-Receptors, Progesterone,
pubmed-meshheading:16469432-Retrospective Studies,
pubmed-meshheading:16469432-Survival Rate
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| pubmed:year |
2006
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| pubmed:articleTitle |
Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer.
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| pubmed:affiliation |
Department of Pathology, College of Medicine, Hanyang University, 17 Haengdang-dang, Seongdong-Gu, Seoul 133-791, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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